Abstract

Background: Human papillomavirus (HPV) is the most prevalent sexually transmitted infection worldwide. Although it is often presented as minor lesions, extensive involvement of the glans-foreskin transition can pose significant aesthetic and functional challenges that conventional treatments may fail to address. Case Report: A 30-year-old man in good health presented with a symptomatic verrucous lesion measuring 3 cm at the glans-foreskin junction. The lesion had grown over a period of six months. A biopsy confirmed HPV without malignancy. The patient underwent wide surgical excision with oncological margins, followed by immediate reconstruction using a dermoadipose graft harvested from the inner arm. Results: At the six-month follow-up, excellent graft integration was observed, with no necrosis, retraction or infection present. The patient reported high aesthetic satisfaction and partial sensory recovery, as well as fully preserved erectile function with no recurrence. Conclusion: Compared to conventional skin grafts, the use of dermoadipose grafts rich in adipose-derived stem cells (ADSCs) provides superior elasticity and biomechanical adaptation, making them an effective solution for complex genital reconstructions.