Abstract

Tirzepatide, a dual GIP/GLP-1 receptor agonist, has shown remarkable efficacy in promoting weight loss and reducing appetite. While its metabolic effects are well established, the central mechanisms driving its anorectic properties remain less understood. This manuscript explores how tirzepatide influences neural circuits involved in reward, motivation, and satiety, with particular attention to mesolimbic and hypothalamic pathways. Neuroimaging and behavioral data suggest that tirzepatide alters food-related salience and decision-making, leading to sustained changes in eating behavior. These effects involve both dopaminergic modulation and enhanced cognitive control. By integrating findings from neuroscience and behavioral science, this work proposes a model in which tirzepatide reshapes appetite regulation through adaptive changes in brain function. The implications for long-term weight management and individualized treatment strategies are discussed.